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1 Results at three months demonstrated that the combination of Sculptra and Restylane Lyft or Contour effectively improved the facial aesthetic appearance of patients experiencing significant medication-driven weight loss with associated facial volume loss, further supporting the benefits of the SHAPE Up HIT: 1 Three months after their final treatment, subjects showed improved mid-face shape and contouring along with improvements in cheek wrinkles and an overall improvement in facial appearance 1 Skin quality findings, which were assessed and reported in the Sculptra/Restylane Lyft regimen, demonstrated improvements beyond visual improvement

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Table 1 presents the GLP-1R agonists currently used in T2D treatment and their reported effects on disease-associated cardiovascular and kidney pathology in long-term human studies