Tri-Luma cream containing hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.1% has been authorized by the FDA for melasma management and should be applied once daily on the affected facial areas for at least 8 weeks (Spierings, 2020)
Fiber Fiber plays a dual role by slowing down digestion and feeding beneficial gut microbes

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Our data support a dual-axis model in which a pharmacologic trigger interacts with modulation of the immune-tolerance threshold, suggesting that ICI exposure may lower immune tolerance and thereby amplify subsequent drug-induced, T cellmediated immune responses
Repetitive motion such as throwing, serving, or swinging a golf club can predispose to these micro tears and inflammation