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These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours

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The receptor also shows notably high constitutive (ligand-independent) activity, a feature that distinguishes it from many other G-protein-coupled receptors and that shapes how agonists like MK-677 behave