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Can cause scalp irritation, unwanted facial hair, and rare cardiovascular effects

In aged AD model mice, tau is overexpressed, the cerebral microvessels are disrupted, and abnormal malformed vascular masses form, and cortical atrophy occurs (234)

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More particularly, a strong activation of PKC in the endothelium of diabetic patients is observed in the increased generation of ROS and microvascular OS (Nuez-Musa, 2024), and vasoconstriction potentiates and insulin signaling peripherally impairs (Robson et al., 2018)