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Therapeutic interventions were escalated with hydroxyurea 0.5g PO bid (days 810 post-diagnosis) and idarubicin 8mg/m 2 IV daily (days 911 post-diagnosis) for leukocyte cytoreduction, supplemented by hepatoprotective agents including ursodeoxycholic acid and glutathione infusion

5.6% among non-users (p = 0.702)

The intricate interaction between the HPA axis, neuroinflammation, mitochondrial functioning and oxidative stress might be crucial in mechanisms underlying the beneficial effects of the nutritional interventions in the context of ES

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