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PIB Backgrounder : 01 APR 2026 10:48AM by PIB Delhi Introduction Diabetes is a chronic disease that occurs when the pancreas does not produce adequate insulin, or when the body cannot effectively use the insulin it produces, leading to high blood sugar

While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

All these changes result in deepening of fine lines, sagging facial contours, and a plump, radiant, natural glow of your skin, which becomes difficult to maintain

however, it can also be a risk factor for thromboembolism