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In summary, GLP-1RAs provide substantial weight loss and cardiometabolic benefits but may compromise skeletal muscle integrity, whereas exercise supports muscle maintenance and functional health, though its effect on weight reduction is typically modest compared with pharmacotherapy

It was first proposed as a sleep-peptide and this remains the prevalent impression of its function

Eri, L.M

The question of whether these agents can be safely used together requires careful consideration of pharmacological properties, clinical evidence, and FDA guidance regarding thyroid-related safety concerns specific to GLP-1 receptor agonists