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In vivo , findings demonstrate that the overexpression of indoleamine 2,3-dioxygenase (IDO) restricts ATP production in CD8+ cells, whilst in vitro studies indicate this effect is mediated by reduced activity of electron transport chain complex I, which accounts for the decreased ATP production observed in infiltrating T cells (Liu et al., 2009)
Importantly, we did not observe changes in the total levels of NRF2 protein (S
3-OHKY, 3-hydroxykynurenine
Nng cc cht in gii cn c duy tr lin tc mc thch hp m bo c th hot ng bnh thng
Poorichaya Singcha for assisting with the analysis of -EC and GSH contents
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