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Parallel animal models in the same study revealed that glutathione supplementation increased mitochondrial DNA by 53% and improved intermuscular pH, effectively preventing the acidic environment that leads to rapid muscle burning and exhaustion

In addition, senescence-associated secreted factors, such as interleukin 6 (IL-6), interleukin 8 (IL-8), also displayed similar expression profiles, particularly in Cys 2 -starved and erastin-treated cells (Fig

When glutamine is deaminated by glutaminase the resulting glutamate can be further deaminated by glutamate dehydrogenase yielding 2-oxoglutarate (-ketoglutarate) which can then be shunted to malate synthesis in the TCA cycle

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K., Foote, R