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It should be emphasized that during corticosteroid therapy prolonged for more than 2 weeks, there is a risk of developing adrenocortical insufficiency, which is manifested by the inhibition of ACTH secretion and adrenal atrophy

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To achieve the best results, it's recommended to use only one patch within a 24-hour period or less

Metformin induces vitamin B12 malabsorption, which may increase the risk of developing vitamin B12 deficiency, a clinically important and treatable condition