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Structural alterations of the ligand peptides as in GIP/GLP-1 dual-receptor agonists may alter these cellular processes strongly and may explain that an antagonist may activate while an agonist may block receptor signaling (4649)

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By enhancing the depth of SWS, they could be particularly beneficial for individuals whose sleep cycles are disrupted by stress, aging, or underlying conditions

In wild-type and ob/ob mice, adiponectin heightens uncoupling protein 1 (UCP1, thermogenin) mRNA levels in BAT and encourages thermogenesis, without modifying food intake

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