doi: 10.1056/NEJMoa0806375
the path from rodent studies to validated human outcomes is long and uncertain
If those people lose even 10% to 15% of lean mass, its still significant because they have low mass to begin with. But lost muscle mass isnt good for anyone, no matter your age
Ethics declarations Ethics Approval The study protocol was approved Kafkas University Animal Experimentation Ethics Board (KAU-HADYEK 2017-034)
Gust J, Rawlings-Rhea SD, Wilson AL, Tulberg NM, Sherman AL, Seidel KD, Wu QV, Park JR, Gardner RA, Annesley CE (2023) GFAP and NfL increase during neurotoxicity from high baseline levels in pediatric CD19-CAR T-cell patients