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Clinical trials show that approximately 2540% of participants experience nausea during dose escalation weeks, with most reporting resolution by day 1014 of each new dose level

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4.3 SURPASS-3 trial comparison of tirzepatide and insulin degludec The SURPASS-3 trial involved 1,444 patients with type 2 diabetes who had HbA1c levels ranging from 7% to 10.5% and a BMI of 25 kg/m 2 or higher

In animal studies, GLP-1s caused thyroid tumors in rodents