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concurrently, it suppresses TFAM transcription, resulting in reduced mtDNA replication and ETC complex assembly defects

These abnormalities can cause decreased production of 5-methyltetrahydrofolate, impair the production of folate cycle metabolites and decrease folate transport across the bloodbrain barrier and into neurons

We prescribe both medications and help you choose based on your symptoms, dose needs, budget, and how your body responds