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Modulation of enzymes involved in NAD + consumption and synthesis In addition to NAD + precursor-based strategies, halting of processes linked to NAD + consumption or biosynthesis represents a complementary and therapeutically appealing approach to alter or restore NAD + homeostasis in context-specific applications

Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor

Larger injection volumes can be uncomfortable and impractical, especially if multiple injections are needed to get the full dose

Supplementary Table S5)