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Role of liraglutide in brain repair promotion through Sirt1-mediated mitochondrial improvement in stroke

Mechanistically, DAMPs interact with toll-like receptors (TLRs) and purinergic receptors on Kupffer cells, resulting in the secretion of pro-inflammatory mediators such as IL-6, IL-18, IFN-, TNF-, and Fas ligands, which further promote macrophage proliferation [54]

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