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Dizziness and fatigue have also been reported, which may relate to changes in blood glucose levels, blood pressure, or caloric intake rather than direct central nervous system effects

In practice, doctors also weigh comorbidity, prior treatment, contraindications, and whether long-term follow-up can be done safely

Ondansetron is most effective when taken 30 minutes before anticipated nausea or at the first sign of symptoms, and it typically works within 12 hours

Rapid ligand-receptor binding and efficient uptake by target cells are critical for receptor-targeted delivery systems to avoid in vivo clearance

Wegovy users have also reported hospitalization due to gastroparesis (stomach paralysis), was not mentioned on the drugs warning label until October 2025