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Karalis, RD, says, Individualized nutrition counseling and behavioral support from a dietitian have been shown to enhance weight loss and appetite control when combined with semaglutide

However, DPP-4 inhibitors (such as sitagliptin or linagliptin) should be discontinued when initiating semaglutide, as both drug classes work through incretin pathways, and combined use offers no additional glycemic benefit while potentially increasing adverse effects

Using it off-label for weight loss has contributed to supply shortages for diabetes patients

This distinction is important