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For the second group, those with a pre-existing substance use disorder, the researchers tracked which of the 81,617 participants experienced drug-related emergency department visits, hospitalization, mortality, overdose, or suicidal ideation or attempt
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However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance
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