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MIC of combined agents was determined and compared with the MIC of antibiotics alone

Normally, Nrf2 is sequestered in the cytoplasm by Keap1 (Kelch-like ECH-associated protein 1), a protein that also acts as an adaptor protein for the Cullin 3-dependent E3 ubiquitin ligase to mediate the ubiquitination and degradation of Nrf2