Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals
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[DOI] [PubMed] [Google Scholar] de Jong TM, Jochens A, Jockel-Schneider Y, Harks I, Dommisch H, Graetz C, Flachsbart F, Staufenbiel I, Eberhard J, Folwaczny M, Noack B, Meyle J, Eickholz P, Gieger C, Grallert H, Lieb W, Franke A, Nebel A, Schreiber S, Doerfer C, Jepsen S, Bruckmann C, van der Velden U, Loos BG, Schaefer AS
There is an urgent need for a pharmacological agent that can specifically and safely correct the shared metabolic pathology, ideally by acting at both central (e.g., controlling appetite and cravings) and peripheral (e.g., improving insulin sensitivity, reducing hepatic fat and inflammation) levels to support and enhance existing behavioral strategies, thereby lowering the risk of advanced liver disease development across metabolic and alcoholic etiologies
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