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Gruendel, S., Garcia, A.L., Otto, B., Mueller, C., Steiniger, J., Weickert, M.O., Speth, M., Katz, N

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GLP-1 medications slow gastric emptying (how quickly food leaves your stomach), which can impact how nutrients are absorbed

Advances in detection, prevention and treatment of heart failure in type 2 diabetes: part I ALICE C COWLEY, ABHISHEK DATTANI, EMER M BRADY, GERRY P MCCANN, GAURAV S GULSIN Department of Cardiovascular Science, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK Address for correspondence: Dr Gaurav S Gulsin Department of Cardiovascular Science, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK E-mail: [email protected] Abstract Management of heart failure (HF) in diabetes has previously centred on aggressive control of cardiovascular risk factors

It has been shown that GLP-1 analogue exenatide could activate the human monocyte-derived macrophage towards M2 phenotype ( -/- mice with a concomitant upregulation of M2 marker CD163 ( +/- mice, a -cellspecific glucokinase haploinsufficient (Gck+/) diabetic model ( 2.2 The role of GLP-1 in innate-like T lymphocytes Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes that bridge the innate and adaptive immune systems ( 2.3 The role of GLP-1 in intestinal epithelial lymphocytes As a innate like lymphocytes, intestinal epithelial lymphocytes (IELs) patrol the lamina propria and play a critical role in host-bacteria interaction, wound healing, mucosal growth and regeneration, and inflammation ( -/- mice, while the numbers of CD4+ and CD8+ T cells and B cells in the spleen and lymph nodes had no differences ( 3 The role of GLP-1/GLP-R axis in related signal pathways GLP-1 is known to increase insulin secretion by cells under hyperglycemic conditions