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Subsequently, DP breaks cysteinyl glycine into cysteine and glycine, which are reabsorbed into the cell to engage in a novel GSH synthesis pathway (summarized in Fig

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Within these pathways, dehydroepiandrosterone (DHEA) activates GPER, triggering the AMPK-Nrf2 (nuclear factor erythroid 2-related factor 2) signaling cascade, which enhances the hepatic antioxidant capacity and alleviates oxidative stress [80]