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In November 2023, the FDA approved tirzepatide for chronic weight management under the brand name Zepbound

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Patients who may not be appropriate candidates include: Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Those with a history of severe hypersensitivity reactions to semaglutide Patients with a history of pancreatitis (relative contraindication requiring careful risk-benefit assessment) Pregnant women or those planning pregnancy (contraindicated for weight management