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Moreover, tirzepatide outperformed semaglutide when it came to weight loss, with tirzepatide doses of 15 mg, 10 mg, and 5 mg delivering notable reductions in body weight (-10.96 Kg, -8.75 Kg, and -6.16 Kg, respectively) compared to semaglutide (-5.24 Kg, -4.44 Kg, and -2.72 Kg for semaglutide at 2.0, 1.0, and 0.5 mg, respectively)

Study mechanistic interactions between estrogen signaling and incretin pathways in humans, translational work that can guide dosing and adjunctive therapies