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There is no cause-and-effect relationship between this class of drugs and suicidality 1416 or increased incidence of psychiatric disorders

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The process is dynamic, and involves also the thiolate groups of proteins such as serum albumin and haemoglobin and appears as the main mechanism for the distribution of thiol-binding metals from the absorption site throughout the body and towards the active sites where the toxic action is developed at the molecular level

Liver tissue samples were homogenized in a lysis buffer containing 50 mM Tris/HCl (pH 7.4), 150 mM sodium chloride, 1 mM EDTA, 5 mM sodium pyrophosphate, 1 mM sodium orthovanadate, 50 mM sodium fluoride, 1% NP-40, 1 mM PMSF and a protease inhibitor cocktail tablet (Roche Diagnostics Ltd.)