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Impairment in Glutathione peroxidase 4 (GPX4) function, which attenuates cellular redox defense, i s also associated with cartilage extracellular matrix (ECM) damage (Miao et al., 2022) implying targeting ferroptosis as a promising new direction for possible interventions in OA pathogenesis

Antagonism of CB1 causes a dose-dependent rise in corticosterone levels in mice (102)

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