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Nevertheless, the overall trend suggests a reduction in basal insulin dose by up to 17% and a decrease in prandial insulin dose by up to 30% in addition of GLP-1RA to insulin therapy, especially with long-acting forms [32]

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For patients in dose-escalation phases, crossing time zones may require dose timing adjustments

Studies showed that patients on the injectable version of GLP-1s lose an average weight loss of 15% of body weight at 68 weeks, so it takes them over a year