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Males should use condoms during treatment with ONIVYDE and for at least 4 months after the last dose

It was observed to possibly decrease fragmentation in post-ovulatory aged oocytes and during parthenogenetic activationa process where an egg develops into an embryo without fertilization

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However, with the advent of NuSH therapies that offer pleiotropic effects, a multi-organ or systemic approach may prove more practical