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The longstanding concern about NSAIDs in the third trimester remains, as they can cause premature closure of a fetal blood vessel, potentially leading to serious complications in the newborn
doi:10.1016/0168-9452(86)90016-6
Dose-response relationships: Biological effects show threshold (minimum effective concentration), linear response zone (increasing dose produces proportional benefits), and saturation (maximum benefit reached, further increases provide minimal additional effect)
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