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A 2025 UCSF open-label pilot in Parkinsons disease, the first test of a psychedelic in a neurodegenerative disease, found that two sessions improved mood, cognition, and motor symptoms for weeks to months, with a larger randomized trial now under way

The overall direction of these changes moves gene expression patterns from states associated with disease and aging toward healthier profiles

He said he lost the urge to snack, but still had energy to work out

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7 hours | Primary site of action: cytoskeleton, actin polymerization | Key receptors: G-actin, ILK-PI3K-Akt | Research focus: tissue repair, cell migration | Endogenous: yes (Thymosin Beta-4 fragment) | Gene modulation: moderately documented What Safety Aspects Are Known from Research