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The article states that these substances are already widely available, heavily marketed on social media, and are labeled as research use only to get around legal barriers

635 Further exploration of such potential mechanisms that involve astrocyte is warranted

Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low

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