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The SUSTAIN-6 trial showed that semaglutide reduced heart attacks and strokes by 26% in people with type 2 diabetes and existing heart disease, even when LDL levels remained similar to placebo groups

doi: 10.1016/j.autrev.2020.102649 36 McLeodDSACooperDS

Recommendations : Use for 412 weeks , then take 4+ weeks off before restarting Monitor subjective feedback: sleep, digestion, energy, training response Reassess if using with other peptides or GH secretagogues to avoid overstimulation Who Should Be Cautious

doi: 10.1186/s12866-020-01816-5 24 IchinoheTPangIKKumamotoYPeaperDRHoJHMurrayTSet al

doi:10.1159/000357979