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A 2022 randomized trial of exenatide did not meet its primary endpoint for reducing heavy drinking days in the overall population, though exploratory analyses suggested potential benefits in participants with obesity

Across corticosteroids, acetaminophen, NSAIDs, and opioids, a consistent pattern emerges: Inflammation is suppressed, but tissue repair is impaired Pain signals are blocked, but nervous system sensitivity increases Symptoms are quieted, but root causes remain unaddressed Over time, this creates a widening gap between symptom relief and true recovery

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