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Researchers have tried to overcome this by co-administering insulin or large carbohydrate loads to stimulate muscle carnitine uptake, and some studies using this protocol have shown modest increases in muscle carnitine content but the translation to real-world performance or fat loss has been underwhelming

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In a major clinical trial published in The New England Journal of Medicine , adults taking one GLP-1-based medication lost an average of 14.9% of their body weight over 68 weeks , showing just how dramatic the results can be when the treatment is clinically appropriate and consistently used