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Among the 226 treatments we have analyzed, 67% of RCTs involve very late treatment 5+ days after onset

In alveolar epithelial cells and endothelial cells, mitochondrial dysfunction serves as a major source of ROS

Safety Profile: Preclinical studies suggest high specificity, but the potential for overkill in tissues where transient senescence is required for wound healing or tumor suppression remains a point of scholarly debate (Rabinovitch, 2023)

doi: 10.1016/j.jep.2018.10.033 273

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