Warning signs requiring urgent evaluation include persistent vomiting that prevents fluid intake, severe upper abdominal pain (particularly if radiating to the back), signs of hypoglycemia that don't resolve with carbohydrate intake, symptoms of dehydration (decreased urination, extreme thirst, dizziness), or any other concerning reactions
Meta-analyses of clinical trials have collectively found that CPAP therapy is associated with small but significant reductions in both systolic and diastolic blood pressure, particularly in those with moderate-to-severe obstructive sleep apnea
Some people may see substantial benefits even at lower doses
The tradeoff is specificity
Though both liraglutide and empagliflozin reduce blood pressure, a risk factor to HF, the difference in HF hospitalization cannot be accounted for even when blood pressure is pre-controlled, and Scheen et al