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10.1016/j.jconrel.2014.03.026 J Control Release

The electron transport chain (ETC) is integral to aerobic respiration in eukaryotic cells, located within the inner mitochondrial membrane (IMM)

Moreover, innate immune receptors such as toll-like receptors (TLRs) or nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) detect signs of cell death or damage, for example nucleic acids or mitochondrial DNA, which causes the release of pro-inflammatory cytokines [10]

This has been dismissed by Chaplin [Chaplin, 2012] partly on the grounds that generation of osmotic pressure at aqueous interfaces might be a better explanation, and abhorrence of Pollacks use of the idea of 2-D hexagonal water clusters to explain his findings (this first appeared during the abortive debate over polywater more than forty years ago [Web reference 7], which was later debunked [Rousseau and Porto, 1970])

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