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Journal of Functional Foods, 105, 105569

The reduction of cell growth and viability showed in TC cells were due to the regulation by metformin of the AMPK-mTOR pathway, inhibiting cell cycle progression and inducing apoptosis (Klubo-Gwiezdzinska et al., 2012

Thus, the etiology of primary cerebral folate deficiency includes the presence of autoantibodies against the folate receptor (FR1) and mutations in the FOLR1 gene, which encodes the FR1 protein [101]

Prokinetic agents like metoclopramide present a theoretical option but should be used cautiously given potential adverse effects (including tardive dyskinesia with use beyond 12 weeks) and the counterintuitive nature of accelerating gastric emptying while using a medication that intentionally slows it