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The amount of semaglutide GLP-1, or the dosage required, plays a crucial role in determining the total cost

This introduces clinical heterogeneity and considerably attenuates the practical interpretation of pooled estimates, given the well-established beneficial effects of GLP-1 RAs in reducing both HbA 1c and body weight, as opposed to the neutral effect of a placebo intervention [4,5,6]

doi: 10.1016/0009-8981(85)90020-8

DOI: 10.1136/bmjmed-2025-002150,

However, the market faces notable restraints including complex and costly biosimilar development, stringent regulatory requirements for approval, manufacturing challenges related to achieving high similarity, and physician as well as patient hesitancy toward switching from established originator brands