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And this stability allows the drug to go into the brain, where it squelches appetite and cravings directly, says Sandoval

Ondansetron is one of the most commonly prescribed medications for hyperemesis gravidarum (severe pregnancy-related nausea and vomiting)

This finding aligns with previous studies, suggesting that short-acting agents may more readily cross the blood-brain barrier, thereby activating central GLP-1 receptors and exacerbating symptoms such as nausea and anorexia ( , dosed twice daily), which likely contributes to its higher vomiting risk due to frequent dosing and greater fluctuations in plasma concentrations

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