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A Gamma-Secretase-Like Intramembrane Cleavage of TNFalpha by the GxGD Aspartyl Protease SPPL2b

It is widely studied in laboratory environments for its role in cellular signaling and tissue response pathways

In streptozotocin-induced diabetic mice, liraglutide treatment for 28 days was found to inhibit high glucose and interleukin (IL)-1-induced EndMT in endothelial cells and consequently attenuate neointima formation via activation of the AMPK pathway, which was evidenced by a reduction of the expression of mesenchymal markers such as smooth muscle 22 (SM22), vimentin, and Snail [51]