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Rivaroxaban shares the CYP3A4/P-gp metabolism pathway with apixaban and would carry similar theoretical pharmacokinetic concerns

Eur J Clin Pharmacol 1988;35(5):555-562

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AMP incubation with DTT at neutral pH for 24 h resulted in the formation of its DKP-AMP, showing the same reactivity than AX through intramolecular cyclization ( Figure 3A and Figure S3 )