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In comparison, 634 patients with PCOS who continued metformin treatment during early pregnancy exhibited a birth defect rate of 0.5% (Newman and Dunne, 2022)

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PLoS Pathog 15:e1007581 Fortalezas S, Marques-da-Silva D, Gutierrez-Merino C (2018) Creatine protects against cytosolic calcium dysregulation, mitochondrial depolarization and increase of reactive oxygen species production in rotenone-induced cell death of cerebellar granule neurons

6,18,19 Hyperbilirubinemia is likely secondary to impairment of bilirubin conjugation and clearance by the liver leading to indirect hyperbilirubinemia