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These are essential risk factors, but they do not tell the entire biological story

The healing process is particularly interesting in two closely related tissues: muscle and tendon

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The ensuing vascular hyper-permeability of plasma molecules and leukocytes may lead to acute tissue edema and inflammation 325

The PPP in erythrocytes is the only pathway for these cells to produce NADPH, therefore, any defect in the production of NADPH, such as due to deficiencies in glucose-6-phosphate dehydrogenase, will have profound effects on erythrocyte survival