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Although these findings are promising, evidence for the combination is currently limited to preclinical research, and well-controlled human clinical studies are needed to confirm its safety and effectiveness
190 Besides, BECs have been identified as the main source of osteopontin (OPN) following PHx, which activates macrophages to produce IL-6 and supports liver regeneration
This effect often diminishes with continued use as the system adapts
however, safety concerns still accompany this therapeutic approach
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