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All of the studies used both in vivo and some form of in vitro methods of data collection in order to observe different treatment effects, allowing for biomechanical, functional (use of AFI index and load to failure), macroscopic and microscopic histological analysis

This review is also significant because it positions GHK-Cu in the context of gene data from the Broad Institute's Connectivity Map the same database used by pharmaceutical researchers to discover new drug applications

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