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Challenging with a solo dose of MTX induced 47% and 58% boost in BUN and creatinine, respectively, compared with the control

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Once phosphorylated the tyrosine residues of the beta subunit serve as docking sites for downstream signaling mediators including extracellular signal-regulated kinase (ERK) and the phosphatidylinositol-3-kinase (P13K) pathway [78] ( Figure 2 )