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A healthy microbiome produces short-chain fatty acids that reduce systemic inflammation and support skin barrier function

TMAO is a metabolite produced by gut microbiota

During training, each rat started at one of four starting points (north, south, east, or west) and was allowed to swim until it located the platform or until 60 s had elapsed

The latter phenomenon results in a characteristic sclerotic aspect of the upper and lower thirds of the vertebrae, contrasting with rarefaction of the vertebral center (rugger jersey spine)

Declines in mitochondrial function i.e., decreases in mitochondrial DNA volume and integrity are linked to accelerated aging