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In the first enzyme reaction, methylcobalamin is used to recycle the folate cofactor 5-methyltetrahydrofolate to tetrahydrofolate thereby allowing the folate cofactor to participate in a cycle involving the biosynthesis of purines and pyrimidines

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iron metabolism factors, such as Fe 2+ which promotes the production of ROS through the Fenton reaction and so on, which in turn promotes lipid peroxidation [88]

It works by selectively inhibiting aldosterone synthase to reduce excess salt and water retention

The lipid soluble vitamins, shown in the diagram below, are not as easily eliminated and may accumulate to toxic levels if consumed in large quantity